Job Description

Join to apply for the Vice President, RAP-314 Program Leader role at Rapport Therapeutics

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Join to apply for the Vice President, RAP-314 Program Leader role at Rapport Therapeutics

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When our people share why they joined Rapport and love it here, it comes down to three things: the science, the mission, and the team. At Rapport, we’re driven by a passion for developing precision neuromedicines with the potential for fewer side effects, enabling patients and their families to enjoy healthier, more fulfilling lives. And we’re doing this with extraordinary science and awesome people (affectionately called Rapptors).

Our innovative scientific platform is centered on Receptor Associate Proteins (RAPs). RAPs are a component of neuronal receptor complexes, which play a crucial role in regulating receptor assembly and function. This precision approach has the potential to revolutionize the development of small molecule therapies. We are excited about the potential of our lead program, RAP-219. Our first indication targets focal epilepsy with additional clinical trials for neuropathic pain and bipolar disorder.

The strength of Rapport comes from our Rapptors – who are united by our mission to improve patients lives. We bring the heart and hustle to advance our science forward, always staying true to our core values. We hope you’re as excited about this opportunity as we are!

Your Impact

In this enterprise leadership role you will lead a cross-functional team to develop the integrated development plan for RAP-314, a foundational program in the company’s pipeline, a program with the potential to improve the lives of millions of patients living with pain and create significant value for RAPP.

Your Day-to-day

• Serve as the single accountable leader for RAP-314 from early-stage development through through Phase 2/3 and registration.
• Opportunity to shape and lead integrated development plan for RAP-314 from IND through product approval.
• Define and drive the integrated development strategy, ensuring alignment with target product profile, global regulatory expectations, and corporate goals.
• Lead program-level decision-making, risk assessment, and scenario planning in coordination with senior leadership.
• Lead and align cross-functional teams including clinical, regulatory, CMC, biometrics, and medical affairs.
• Provide innovative and flexible operational solutions and options to the cross functional and development teams; assist in preparing scenarios for creative solutions to operational challenges.
• Oversee timelines, budgets, and resources across functions to ensure milestones are met.
• Oversee preparation of key regulatory filings (IND amendments, End-of-Phase 2 meetings, NDA/MAA submissions).
• Represent the program in regulatory agency meetings alongside clinical and regulatory leads.
• Present program updates, timelines, risks, and mitigation plans to the executive leadership team, board of directors, and investors.
• Build strong relationships with key internal stakeholders and external partners (CROs, CDMOs, consultants, etc.).

Must-Haves

• PhD, PharmD, MD, or equivalent advanced degree in a relevant scientific or clinical field.
• 15+ years of biotech/pharmaceutical industry experience, with proven leadership in small molecule drug development.
• Significant experience leading cross-functional programs through early and middle stages of development (Phase 1/2) and toward regulatory approval.
• Demonstrated success in program leadership roles, particularly startup biotech environments.
• Strong understanding of regulatory pathways and expectations for small molecule therapeutics.
• Exceptional interpersonal, communication, and influencing skills.
• Experience managing complex timelines, budgets, and partner relationships.
• Familiarity with working across multiple geographies (e.g., US and EU regulatory bodies).
• Experience managing/mentoring in a highly matrixed environment

What Makes Rapport Special

• Every role has meaning. We’re determined to discover a better way for patients, and you’ll feel the passion from the start.
• We are driven to innovate. Exciting science that pushes boundaries and opens new possibilities.
• Your perspective matters. Stick your neck out, share your ideas – we work as a team.
• We have FUN. We hire smart, dedicated, down-to-earth people that you’ll enjoy spending time with.
• Leadership that CARES – about you, your growth + development.
• We're bicoastal. Whether you're in the lab full-time in San Diego or taking advantage of a more hybrid work schedule in Boston – we make the most of our time together.
• Competitive benefits. Including unlimited PTO, a lifestyle spending account, commuting reimbursement, and much more!
• You get to be YOU! Show up as you are and make every day count.
• This role is based in Boston, MA with a hybrid work schedule*

Rapport Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

CCPA disclosure notice can be found here.

Seniority level

• Seniority level

  Executive

Employment type

• Employment type

  Full-time

Job function

• Job function

  Project Management and Information Technology

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Job Tags

Full time, Local area, Remote work, Flexible hours,

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